hPD-L1(E3-4)

品系全名

C57BL/6Smoc-Cd274em2(hPD-L1)Smoc

目錄號(hào)

NM-HU-190039

品系狀態(tài)

胚胎凍存

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基因信息

基因名
Cd274

基因曾用名

B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

NCBI ID

MGI ID

Ensembl ID

Pubmed

人類同源基因

CD274

品系描述

通過(guò)同源重組，將小鼠基因Cd274進(jìn)行人源化修飾。與此相似的品系還有hPD-L1(NM-HU-00062),詳細(xì)信息請(qǐng)咨詢技術(shù)顧問。
應(yīng)用領(lǐng)域：腫瘤研究；免疫治療；藥物篩選；

驗(yàn)證數(shù)據(jù)

PD-L1-HU-1.png

Fig1.?The expression of human PD-L1 in the peripheral blood cells derived from homozygous humanized mice were confirmed by flow cytometry analysis.?

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Fig2. Immunotype in blood , spleen and bone marrow in hPD-L1 mice.?

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Fig3. Immunotype in blood in hPD-L1 mice.?

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Fig4. Immunotype in spleen in hPD-L1 mice.?

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Fig5. Immunotype in bone marrow in hPD-L1 mice.?

PD-L1-HU-2.png

PD-L1-HU-3.png

Fig6.??In vivo?anti-tumor effect of an anti-human PD-L1 antibody in the humanized PD-L1 mouse model. (Tecentriq is a monoclonal antibody specific for human PD-L1)(A)? PD-L1 humanized MC38 cells were subcutaneously implanted into humanized PD-L1 mouse model. Treatment of hPD-L1 antibody inhibited PD-L1 humanized MC38 tumor growth, demonstrating that the humanized PD-L1 mice are a good in vivo model for validating the efficacy of antibodies targeting human PD-L1. (B) Mean body weight of mice.? All quantitative data are represented as mean ± SEM.

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